5-(Hydroxymethyl)furan-2-carbaldehyde

5-HMF | 5-Hydroxymethylfurfural | CAS 67-47-0 is derived from sugars and the link between biomass and furan-based chemicals. With its functional groups and reaction sites, 5-HMF is a versatile, renewable building block.

Intermediates – 5-HMF can be converted into interesting downstream products:

• 2,5-Furandicarboxylic acid, which has been proposed as a replacement for Terephthalic acid in the production of polyesters
• 2,5-Dimethylfuran a liquid that is a potential biofuel with greater energy content than bioethanol
• 2,5-bis(hydroxymethyl)furan
• gamma-Hydroxyvaleric acid and gamma-Valerolactone by catalyzed hydrolysis
• 2,5-Furandimethanol
• 5-Methyl furfural
• 2,5-Hexanedione
• (5-Methylfuran-2-yl)methanol
• Dimethyl furan-2,5-dicarboxylate

​Industrial uses

• Bio-based 5-HMF is considered to be an interesting substitute for Formaldehyde in PF resins.

Food, Feed & Beverages

• 5-HMF is a promising substance for a range of innovative functional food and feed applications.

Pharma & Healthcare

• As an active pharmaceutical ingredient (API) the bio-based molecule has the potential for novel applications in the pharmaceutical industry.
• 5-Hydroxymethyl-2-furancarboxylic acid can be used as a building block in the enzymatic synthesis of macrocyclic oligoesters.
• 5-HMF is an intermediate in the titration of hexoses in the Molisch's test.
• A major metabolite in humans is 5-hydroxymethyl-2-furoic acid (HMFA), which is excreted in urine.
• 5-HMF binds intracellular sickle hemoglobin (HbS). Preliminary in vivo studies using transgenic sickle mice showed that orally administered 5-HMF inhibits the formation of sickled cells in the blood. Under the development code Aes-103, HMF has been considered for the treatment of sickle cell disease.

Shelf Life

1-year shelf life at ambient temperature

Health & Safety

Detailed information on the product described can be found in our relevant Health and Safety Information (Material Safety Data Sheet).